FDA Approves Gilead’s Twice-Yearly HIV Prevention Shot Yeztugo, But Pricing Raises Access Concerns

The U.S. Food and Drug Administration (FDA) has approved Gilead Sciences’ lenacapavir — a twice-yearly injectable drug to prevent HIV infection — in a move hailed as a historic breakthrough in the decades-long battle against the virus. Marketed under the brand name Yeztugo, the drug is the first twice-yearly pre-exposure prophylaxis (PrEP) treatment to receive FDA approval. “This is a historic day in the decades-long fight against HIV,” said Daniel O’Day, Chairman and CEO of Gilead Sciences, following the announcement. A Potential Game-Changer in HIV Prevention Unlike previous PrEP options like Truvada, which require daily pills, Yeztugo offers a bi-annual injection that has demonstrated exceptional efficacy. In clinical trials involving over 4,000 participants: Only two infections were reported across all study participants. The results, published in The New England Journal of Medicine, earned lenacapavir the 2024 “Breakthrough of the Year” title by Science magazine. Reported side effects included mild injection site reactions, headache, and nausea. Affordability and Equity Concerns Despite its promise, the $28,218 annual list price in the U.S. has raised significant concerns among activists, researchers, and public health experts, particularly those fighting for access in low- and middle-income countries. Gilead spokesperson Blair Baumwell said the pricing is “in line” with other PrEP products, and the company expects broad insurance coverage to support access. However, critics argue the pricing is a major obstacle. “Even high-income countries will not be able to afford widespread use of lenacapavir at prices above $20,000 per year,” warned Andrew Hill, researcher at Liverpool University, who has shown that the drug could be mass-produced for as little as $25 per year. Global Access Plans Underway In an effort to expand global access, Gilead signed agreements in October 2024 with six pharmaceutical companies to manufacture generic versions of lenacapavir for 120 low- and middle-income countries, pending regulatory approvals. Additionally, a separate deal with the Global Fund, the UN, and PEPFAR (President’s Emergency Plan for AIDS Relief) aims to supply the drug to 2 million people. However, budget cuts to PEPFAR under the Trump administration have cast doubt on the sustainability of this effort. A Global Turning Point — If Accessible UN Under-Secretary-General Winnie Byanyima emphasized the importance of equitable pricing: “Lenacapavir could be the tool we need to bring new infections under control — but only if it is priced affordably and made available to everyone who could benefit.” As the HIV/AIDS community celebrates this scientific milestone, pressure is now mounting on Gilead and global health institutions to ensure that cost doesn’t become a barrier to what could be a revolutionary tool in ending the HIV epidemic.

Israel-Iran Conflict Escalates on Day 9: Targeted Strikes, High-Profile IRGC Commanders Killed, Global Alarm Mounts

The ongoing conflict between Israel and Iran entered its ninth consecutive day on Saturday, June 21, 2025, with no sign of de-escalation as both nations exchanged missile and drone strikes. The Israeli military targeted critical nuclear infrastructure in Iran, while Tehran retaliated with missiles armed with cluster munitions — marking the first confirmed use of such controversial weapons in this round of hostilities. In a major development, an Israeli military official confirmed that two centrifuge production sites in Iran’s Isfahan province were destroyed in overnight airstrikes. These facilities, believed to be essential for Iran’s nuclear enrichment program, represent a critical blow to Tehran’s capabilities. Meanwhile, the Israel Defense Forces (IDF) announced the elimination of two high-ranking Quds Force commanders, deepening the military dimension of the conflict: Following the strikes, the IDF issued a strongly worded statement on X, saying: “Ruled by an extremist regime, Iran threatens global security with its nuclear ambitions and desire for regional domination. They must be stopped.” The United States is closely monitoring the rapidly intensifying conflict. According to a senior U.S. official, President Donald Trump convened a high-level national security meeting at the White House on Friday to review the situation and assess whether the U.S. should intervene. The outcome of the meeting remains undisclosed, but global stakeholders are watching closely, fearing a broader regional war. As casualties mount and tensions boil over, international calls for restraint are growing louder — yet both sides appear firmly committed to their military objectives, raising grave concerns over regional and global stability.

U.S. Pulls Warplanes from Qatar’s Al Udeid Base Amid Iran Conflict Fears; Trump to Decide on Possible Strike

In a dramatic shift with far-reaching strategic implications, the United States has withdrawn nearly all its military aircraft from the Al Udeid Airbase in Qatar, amid rising fears of Iranian retaliation in the escalating Israel-Iran conflict. Satellite imagery dated June 19, accessed by AFP and confirmed by Planet Labs PBC, shows almost total evacuation of aircraft previously stationed at the base. Just two weeks earlier, satellite photos revealed over 40 military planes — including C-130 Hercules transporters, surveillance aircraft, and aerial refueling tankers — stationed at the base. The June 19 images, however, show just three aircraft remaining. The Pentagon has not issued an official statement, but analysts believe the drawdown is a precautionary move against potential Iranian missile or drone strikes targeting U.S. assets in the Gulf region. Al Udeid, located less than 300 km from Iran, is the largest American military facility in the Middle East. Defense experts told AFP the base is now “extremely vulnerable” given its proximity to Iranian missile launch sites. In a parallel development, the U.S. Embassy in Qatar issued a security advisory, citing “ongoing regional hostilities” and restricted access to Al Udeid “out of an abundance of caution.” American personnel have been instructed to remain vigilant. Trump Signals Decision Imminent on Iran Strike Meanwhile, U.S. President Donald Trump is reportedly weighing a potential military strike against Iran, with a decision expected within the next two weeks. During a Thursday briefing, White House Press Secretary Karoline Leavitt said: “There’s a substantial chance of negotiations that may or may not take place with Iran in the near future. Based on that, [President Trump] will make his decision.” Trump, speaking to reporters after his recent G7 summit visit, remained characteristically elusive: “I may do it, I may not do it. I mean, nobody knows what I’m going to do.”He also hinted on Truth Social that the U.S. is planning something “much bigger than that,” fueling speculation about larger strategic military or diplomatic maneuvers. U.S.-Iran Channels Remain Open Despite rising tensions, communications between Washington and Tehran remain active. Iranian state media reports suggest that U.S. special envoy Steve Witkoff has held multiple conversations with Iranian Foreign Minister Abbas Araghchi since June 13, when Israel launched direct strikes on Iranian nuclear and military sites, triggering the current escalation. While negotiation details remain confidential, both sides appear to be exploring de-escalation options, even as rhetoric and military posturing intensify. With satellite images now revealing a near-empty Al Udeid base, the international community is watching closely. Whether the U.S. moves toward direct military engagement, or opts for backchannel diplomacy, the next few days could prove decisive in shaping Middle East stability and global energy security.

Shell Warns of Global Trade Disruption if Strait of Hormuz Blocked Amid Israel-Iran Conflict

June 20: Global energy giant Shell Plc has issued a stark warning that any disruption in the Strait of Hormuz, amid rising tensions between Israel and Iran, could have devastating effects on global trade, particularly oil and gas supplies. Speaking at the Japan Energy Summit & Exhibition in Tokyo, Shell CEO Wael Sawan stated that the company has contingency plans in place should the situation deteriorate further. “If that artery is blocked, for whatever reason, it has a huge impact on global trade,” Sawan said. “We have plans in the eventuality that things deteriorate.” Energy Flows Under Watch While crude prices have risen in recent days due to the hostilities, actual energy flows remain uninterrupted. However, global energy traders are on high alert, anticipating that the escalation could soon impact maritime logistics. The Strait of Hormuz, a 33-kilometre-wide chokepoint at its narrowest, is once again at the centre of geopolitical and energy security concerns. Roughly one-quarter of the world’s oil supply and a substantial portion of liquefied natural gas (LNG) pass through this narrow waterway. It links the Persian Gulf to the Indian Ocean and serves as the main export route for oil and gas from key producers including Saudi Arabia, Iraq, UAE, Kuwait, Qatar, and Iran. Iran’s Threats and Jamming Activity Iranian leaders have repeatedly threatened to block the strait in retaliation against perceived provocations, raising concerns among energy-dependent nations like India and Japan. Recent reports have also highlighted signal jamming incidents affecting ship navigation through the region. Sawan confirmed the issue, stating: “What is particularly challenging right now is some of the jamming that’s happening.”He emphasized that Shell is being extremely cautious with its shipping operations in the Middle East. US May Join Conflict Sources close to the matter have revealed that senior US officials are considering a direct military strike on Iran, further raising fears of a wider regional war. While no final decision has been made, preparations and intelligence assessments are reportedly underway, with the situation said to be “fluid.” Global Implications Loom As the conflict threatens to spill over into international waters, the global economy stands at risk, particularly through potential disruptions to oil prices, supply chains, and shipping routes. A prolonged or intensified blockade of the Strait of Hormuz could send energy prices soaring, trigger global inflation, and cripple trade routes critical to both developed and developing nations. In the meantime, Shell and other global energy companies continue to monitor the region closely while activating risk mitigation strategies, underscoring the fragile state of energy security in today’s geopolitical climate.

Botafogo Stuns PSG with 1-0 Upset in Club World Cup Thriller

In a dramatic showdown at the Club World Cup, Botafogo delivered a stunning upset by defeating Paris Saint-Germain (PSG) 1-0 on Thursday night, thanks to a solitary goal from Igor Jesus. The Brazilian side’s determined defensive display and swift counterattacks thwarted PSG’s high-powered, star-studded offensive efforts, leaving the French champions frustrated. The match got off to an energetic start as PSG’s Khvicha Kvaratskhelia forced an early save from Botafogo’s goalkeeper, John, in just the second minute. However, the French side struggled to sustain any rhythm in a scrappy, foul-plagued first half. Botafogo’s midfield trio—Marlon Freitas, Gregore, and Allan—played a crucial role in neutralizing PSG’s Vitinha and disrupting the flow of possession, enabling their team to maintain a disciplined defensive structure. The decisive moment came in the 36th minute when Jefferson Savarino delivered a perfectly timed through ball to Igor Jesus. With remarkable composure, Jesus bypassed PSG defender Willian Pacho and slotted a low, deflected shot past PSG’s goalkeeper Gianluigi Donnarumma, leaving no doubt as to his clinical finish. Despite controlling the ball for much of the second half and dominating possession, PSG found themselves unable to break down the resilient Botafogo defense. The victory marks a significant boost for Botafogo’s hopes of advancing from Group B and reaching the knockout stages, especially with their next and final group match against Atletico Madrid scheduled for Monday. Reflecting on the momentous win, Igor Jesus stated, “A lot of people had doubts, but we showed how strong Botafogo is. It was tough. We had to defend well, and we did our job.” With the win, Botafogo now sits in a commanding position as they look ahead to their upcoming challenge, while PSG’s progress in the tournament hangs in the balance.

Escalation in Iran-Israel Conflict: Hospital Hit in Beersheba, Nuclear Sites Targeted

The ongoing conflict between Iran and Israel entered its seventh day on Thursday, with significant escalations on both sides. A hospital in the Israeli city of Beersheba was struck during a barrage of Iranian missile attacks, prompting international concern and strong condemnation from Israeli officials. While Iran claimed it was targeting a military site near Soroka Medical Center, Israeli authorities said the hospital itself sustained serious damage. At least 271 people were injured in attacks across the country, and 24 have been killed since the hostilities began on June 13. In retaliation, Israel launched fresh strikes on Iranian nuclear infrastructure, including the Arak heavy water reactor and a facility in Natanz, both critical sites in Iran’s nuclear program. The Arak reactor, though currently inactive, can produce plutonium – a key ingredient for nuclear weapons. Residents of nearby cities Arak and Khondab were reportedly warned by Israeli forces to evacuate prior to the strike. Iranian state media initially reported 224 fatalities as of June 15. However, the Human Rights Activists News Agency (HRANA), a Washington-based organization, stated that 639 people have been killed in Iran since the start of the conflict. The conflict began when Israel attacked Iranian nuclear sites on June 13, killing several high-ranking generals and nuclear scientists. Iran responded by intensifying its missile attacks, including one that hit the business district of Ramat Gan, east of Tel Aviv, injuring around 20 people. At Soroka Hospital, the damage was described as extensive, with fire spreading across multiple wards, ceilings collapsing, and windows shattered. According to Prof. Shlomi Codish, the hospital’s CEO, about 200 patients will be relocated to other medical centers due to the destruction. Israeli Prime Minister Benjamin Netanyahu condemned the missile strike on the hospital as a “deliberate” and “criminal” act. He vowed to “exact the full price from the tyrants in Tehran,” asserting that the Israeli military had already severely damaged Iran’s nuclear program. Netanyahu further claimed that “no one is immune,” in response to a question about whether Iran’s Supreme Leader Ayatollah Ali Khamenei was a target. Defence Minister Israel Katz went a step further, stating that Khamenei “can no longer be allowed to exist”, accusing him of personally ordering attacks on civilian facilities, including hospitals. Israel also claims that Iran has taken steps toward weaponizing its enriched uranium stockpile, which Tehran insists is for peaceful energy use. In turn, Iran has lodged a complaint with the UN nuclear watchdog, accusing Israel of violating international laws prohibiting attacks on nuclear installations. Iranian armed forces declared their response would have “no limits.” As the region remains on edge, international observers are closely watching for further developments, fearing a broader escalation of the already volatile situation.

Trump Softens Stance on India-Pakistan Peace, Credits Modi and Munir After Weeks of Taking Credit

After weeks of publicly claiming that he “stopped a war” between nuclear-armed neighbors India and Pakistan, US President Donald Trump has shifted his tone, now giving credit directly to Prime Minister Narendra Modi and Pakistan’s army chief, General Asim Munir. Speaking from the Oval Office on Wednesday following a lunch meeting with General Munir, Trump said, “I’m so happy that two smart people decided not to keep going with that war… That could have been a nuclear war. Those are two nuclear powers, big ones, big, big nuclear powers, and they decided that.” Significantly, Trump did not position himself as the central peacemaker—a departure from his earlier narrative. Since May 10, when India and Pakistan agreed to a ceasefire following heightened tensions after the April 22 Pahalgam terror attack, Trump had repeatedly claimed personal credit, citing his diplomacy and the appeal of US trade deals as instrumental in de-escalation. He famously declared, “I stopped the war.” Shift After Modi-Trump Phone Call The change in tone came just hours after a 35-minute phone conversation between Trump and PM Modi. Indian officials, speaking from the G7 summit in Kananaskis, Canada, dismissed any claims of foreign mediation. Foreign Secretary Vikram Misri quoted PM Modi as saying: “India has never accepted mediation nor would it ever accept it. We have complete political unanimity on this.” He also emphasized that no trade deals or US involvement were discussed or factored into India’s military decisions under Operation Sindoor, the country’s robust retaliation following the terror attack. According to Indian officials, the decision to cease hostilities came after Pakistan suffered major damage to nine of its airbases and reached out for a ceasefire through pre-existing military channels, not due to external pressure. Modi’s Firm Message, Trump’s Subtle Climbdown Just hours before his Oval Office statement, Trump had again claimed he “stopped the war.” But the softened rhetoric—praising PM Modi and General Munir as “very smart people” and acknowledging their decisions—indicates a subtle walk-back, likely influenced by India’s diplomatic pushback and transparency. Observers say this evolution in Trump’s language reflects a need to recalibrate the US narrative after India’s firm rebuttal. Analysts note that global diplomats and fact-checkers will be closely monitoring whether Trump continues this revised tone or returns to his earlier self-congratulatory framing. Poll: What Do You Think? Do you believe President Trump’s claims about stopping the war are justified? 🔘 Yes, he played a crucial role🔘 No, it was primarily India and Pakistan’s decision As New Delhi reiterates that the credit for preventing further escalation lies solely with India and Pakistan, the world is watching how long the White House maintains this more balanced version of events.

Kashmiri Students Evacuated from War-Hit Iran Thank Centre, Slam J&K Govt for Poor Transport Arrangements

Indian students evacuated from conflict-ridden Iran have expressed gratitude to the Central Government for ensuring their safe return to the country. However, many students—particularly from Jammu and Kashmir—voiced disappointment over the inadequate onward travel arrangements provided by the J&K government from Delhi to their home districts. After days of tension and a long, exhausting journey from Iran via Armenia and Doha, the students were expecting proper care upon arrival in Delhi. Instead, they were met with old and uncomfortable SRTC buses, a stark contrast to the facilities provided to students from other Indian states who received airport assistance and connecting flights home. The Jammu and Kashmir Students Association shared a video on social media platform X, highlighting the poor condition of the buses. The post read: “After enduring a harrowing 4-day journey from Iran via Armenia & Doha, Kashmiri students have finally reached Delhi, only to be dumped in SRTC buses, unlike students from other states who were received with proper airport facilitation, care, and connecting flights home.” The association further criticized the state government’s response, stating, “Exhausted, distressed, and neglected. Is this the reward for their resilience? What’s stopping the J&K Govt from stepping up? Logistics? Willpower? Or just apathy? If it’s about funds, say it loud—we’ll launch a fundraiser for the JK Govt. We’ve done more with less before.” In response to the backlash, the office of then Chief Minister Omar Abdullah acknowledged the concerns and assured that steps were being taken in coordination with the Jammu and Kashmir State Road Transport Corporation to arrange proper deluxe buses for the students’ travel. The flight carrying the 110 evacuated Indian students—primarily from Urmia Medical University in Iran—arrived in New Delhi after delays. Out of these, 90 students belonged to the Kashmir Valley. According to Nasir Khuehami, convenor of the Jammu and Kashmir Students Union, the students had successfully crossed into Armenia on Tuesday and were temporarily accommodated in Yerevan before being flown to India. Iran has remained a favored destination for Kashmiri students due to its affordable higher education and cultural similarities. Currently, over 4,000 Indian students—nearly half of them from J&K—are pursuing courses in cities like Tehran, Shiraz, and Qom. Amaan Azhar, one of the evacuated students, shared his emotions after landing in India. “I am very happy. I cannot express in words how happy I am to finally be able to meet my family. The situation in Iran is very bad. The people there are like us; there are small children who are suffering. War is not a good thing. It kills humanity,” he said. While the safe evacuation has been widely appreciated, the incident has raised questions about state-level preparedness and sensitivity in handling returning students during international emergencies.

ईरान-इस्राइल तनाव: मिसाइल हमलों के बीच आईडीएफ ने जनता से घरों में रहने की अपील की, इस्राइल का पलटवार शुरू

ईरान से शुक्रवार तड़के इस्राइल पर मिसाइलों की एक नई बौछार की गई, जिससे यरुशलम और तेल अवीव सहित कई प्रमुख शहरों में एयर रेड सायरन बजने लगे। इस्राइल डिफेंस फोर्स (IDF) ने पुष्टि की है कि ईरान की ओर से प्रक्षेपास्त्र दागे गए हैं और देश की वायु रक्षा प्रणालियाँ सक्रिय रूप से इन्हें रोकने में लगी हुई हैं। यरुशलम और तेल अवीव के ऊपर कई विस्फोटों की आवाजें सुनी गईं और स्थानीय मीडिया ने कम से कम चार जगहों पर मिसाइल गिरने की पुष्टि की है। बीयर शेवा स्थित सोरोका मेडिकल सेंटर को भी मिसाइल हमले से नुकसान पहुंचा है। इसके अलावा, तेल अवीव, रमात गन और होलोन में भी मिसाइल गिरने की खबरें हैं। IDF ने जनता से अपील की है कि वे “अगले आदेश तक” घरों के अंदर ही रहें और सुरक्षित स्थानों की शरण लें, क्योंकि रक्षात्मक अभियान अभी जारी है। इस हमले के जवाब में, इस्राइली सेना ने ईरान के अराक भारी जल (heavy-water) परमाणु रिएक्टर पर हमला किया है। यह रिएक्टर पश्चिमी शक्तियों के लिए लंबे समय से चिंता का विषय रहा है क्योंकि इससे प्लूटोनियम आधारित हथियार बनाए जा सकते हैं। Reuters ने ईरानी राज्य टीवी के हवाले से बताया कि इस्राइल द्वारा अराक-खोंदाब क्षेत्र में नागरिकों को खाली करने की चेतावनी देने के कुछ समय बाद ही यह हमला किया गया। इसके अलावा, इस्राइल ने लेबनान के लितानी क्षेत्र में हिजबुल्ला के वरिष्ठ तोपखाना कमांडर यासीन अब्दुल मोनीम एज्ज़ेदीन को मार गिराने का दावा किया है। आईडीएफ के प्रवक्ता अविचाय आडरी ने बताया कि एज्ज़ेदीन इस्राइल पर कई हमलों की योजना में शामिल था और हिजबुल्ला की तोपखाना क्षमताओं को पुनः स्थापित करने में प्रमुख भूमिका निभा रहा था। हिजबुल्ला की ओर से इस पर अभी कोई प्रतिक्रिया नहीं आई है।

India Begins Evacuation of Students from Iran Amid Escalating Tensions with Israel

Amid rising tensions between Iran and Israel, India has begun evacuating its citizens, particularly students, from Iran. At least 100 Indian students from Urmia, including around 90 from Jammu and Kashmir, have safely crossed the border into Armenia and are awaiting repatriation to India. Their flight to Delhi is scheduled for tomorrow. The Ministry of External Affairs (MEA) confirmed that Indian students in Tehran have been moved out of the city with the help of arrangements made by the Indian Embassy, citing growing safety concerns. Indian nationals with personal transport have been advised to evacuate Tehran on their own. Some have already crossed the border into Armenia with assistance from authorities. Nasir Khuehami, national convener of the Jammu and Kashmir Students Association, confirmed the safe passage of students from Urmia Medical University and stated that they are currently en route to Yerevan, the capital of Armenia. There are approximately 10,000 Indians in Iran, including nearly 6,000 students. The Embassy of India in Tehran remains in continuous contact with the Indian community to provide all possible support. Additionally, a control room has been established in New Delhi, and 24×7 emergency helplines have been activated in Tehran, Bandar Abbas, and Zahedan to assist Indians in need.

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