Weizmann Scientists Unveil Blood Test That Could Detect Leukemia Risk and Gauge Pace of Aging

A groundbreaking new study by researchers at Israel’s Weizmann Institute of Science may soon revolutionize how we diagnose blood cancers and understand aging. Published today in Nature Medicine, the research led by Profs. Liran Shlush and Amos Tanay introduces a simple blood test that could replace painful bone marrow biopsies for detecting early signs of myelodysplastic syndrome (MDS) — a precursor to leukemia. The study arrives under extraordinary circumstances, just days after the researchers’ labs sustained serious damage in an Iranian missile strike. Yet, despite the upheaval, their findings are poised to create lasting impact. A New Window into Aging and Disease The scientists have been tracking how blood-forming stem cells change with age. Their earlier research revealed that about one-third of individuals over 40 begin to accumulate mutations in these cells — mutations linked not only to leukemia but also to heart disease and diabetes. In the latest study, Dr. Nili Furer, Nimrod Rappoport, and Oren Milman, together with collaborators in Israel and the U.S., showed that even rare stem cells that temporarily leave the bone marrow and enter the bloodstream carry vital diagnostic information. By applying cutting-edge single-cell genetic sequencing to these cells, researchers could identify signs of MDS — a condition where stem cells don’t mature correctly, potentially leading to severe anemia or progression to acute myeloid leukemia (AML). A Less Invasive, More Insightful Test Until now, MDS diagnosis depended on invasive bone marrow sampling. The new blood test promises to change that. It not only flags MDS early but may also evaluate the risk of progression to leukemia, making it a vital tool for prevention and early intervention. The researchers also found that these circulating stem cells act as an internal “aging clock.” Intriguingly, the cells undergo changes earlier in men than in women — possibly shedding light on why blood cancers are more prevalent among males. Broad Potential, Global Trials The innovation is now undergoing clinical trials at medical centers worldwide. Scientists believe that this technology could eventually be used to detect a wide range of blood-related diseases beyond leukemia. Bridging Medicine and Science Beyond his lab work, Prof. Liran Shlush plays a central role in shaping the future of medicine. He is a senior physician at Assuta Medical Center and Maccabi Healthcare Services, and he now heads the newly founded Miriam and Aaron Gutwirth Medical School at the Weizmann Institute. The school, opening in October, aims to blend scientific research and clinical training into a unified curriculum — preparing a new generation of physician-scientists who can navigate both the lab bench and the hospital ward with equal skill. This landmark study not only underscores the Weizmann Institute’s global leadership in biomedical research but also offers hope that one day, a routine blood test could help detect — and possibly prevent — life-threatening diseases long before symptoms appear.

India Rejects ‘Illegal’ Arbitration Court’s Ruling on Indus Waters Treaty Dispute with Pakistan

India on Friday strongly rejected the authority and decisions of the Court of Arbitration formed under the Indus Waters Treaty (IWT), after the body issued a supplemental award asserting its jurisdiction over the ongoing dispute related to the Kishenganga and Ratle hydroelectric projects in Jammu & Kashmir. In a sharp statement, the Ministry of External Affairs (MEA) said that the arbitration court, constituted by the World Bank in October 2022, was “illegally formed” and acting “at Pakistan’s behest”. It labelled the award as the “latest charade” and a tactic by Islamabad to divert attention from its role as a hub of global terrorism. “India has never recognised the existence in law of this so-called Court of Arbitration,” the MEA said, adding that any award or decision from it is “illegal and per se void”. The ministry emphasized that the court’s very constitution is in “serious breach” of the Indus Waters Treaty, and India has consistently opposed its proceedings. Background of the Dispute The Kishenganga project is being built on the Kishenganga River, a tributary of the Jhelum, while the Ratle project is on the Chenab River—both classified as “Western Rivers” under the IWT, from which Pakistan draws its water share. Pakistan first raised objections in 2015 regarding the design of these projects and initially sought resolution through a neutral expert, as per the treaty. However, it later withdrew that request in 2016 and sought adjudication via a Court of Arbitration. India opposed this move and continued pushing for neutral expert mediation. Eventually, on October 13, 2022, the World Bank appointed Michal Lino as the neutral expert but also controversially constituted the arbitration court the same day—sparking India’s strong protest. India has consistently maintained that it cannot be forced to recognise “illegal and parallel proceedings” that are outside the Treaty’s framework, even as it continues to participate in treaty-compliant neutral expert proceedings. Treaty in Abeyance Post Pahalgam Attack Following the April 23, 2024 terrorist attack in Pahalgam, in which 26 people were killed, India took a significant step by placing the Indus Waters Treaty “in abeyance”. On Friday, the MEA reiterated this stance, asserting that India is no longer bound to uphold its obligations under the Treaty unless Pakistan irreversibly ends its support for cross-border terrorism. The ministry further declared: “No Court of Arbitration, much less this illegally constituted arbitral body which has no existence in the eye of law, has the jurisdiction to examine the legality of India’s actions in exercise of its rights as a sovereign.” Significance of the Treaty The Indus Waters Treaty, signed on September 19, 1960, between Prime Minister Jawaharlal Nehru and President Ayub Khan, remains one of the few lasting diplomatic agreements between India and Pakistan. It governs the distribution of the six major rivers of the Indus basin—giving India full rights over the Eastern Rivers (Sutlej, Beas, Ravi), while Pakistan receives the waters of the Western Rivers (Indus, Jhelum, Chenab). India’s move to review and seek modification of the Treaty began with a notice to Pakistan in January 2023, followed by a more assertive notice in September 2024, indicating a potential reconsideration or withdrawal from the Treaty. As the Treaty approaches its 65th anniversary, the latest developments mark a significant shift in India’s position—linking water diplomacy to its broader national security concerns and demanding accountability from Pakistan on the issue of terrorism.

Praggnanandhaa Becomes India’s No. 1 Chess Player After Historic UzChess Cup Victory

June 28, 2025 — In a landmark moment for Indian chess, 19-year-old Grandmaster Rameshbabu Praggnanandhaa has officially ascended to the No. 1 spot in India, following a stunning win at the UzChess Cup Masters in Uzbekistan. In the final round on Friday, Praggnanandhaa defeated Uzbekistan’s top GM Nodirbek Abdusattorov with the Black pieces, clinching the championship title and etching his name in Indian chess history. With this victory, his live FIDE rating soared to 2778.3, catapulting him to World No. 4 — his highest-ever global ranking. A Generational Shift in Indian Chess This win marks more than just a personal milestone — it symbolizes a changing of the guard in Indian chess. Praggnanandhaa has now surpassed current world champion D Gukesh in the live classical ratings, establishing himself as the new face of Indian chess excellence. A Stellar 2025 for the Teen Prodigy 2025 has already been a breakthrough year for the Chennai-born chess prodigy. Earlier this year, he shocked the global chess community by defeating Gukesh at the Tata Steel Masters in Wijk aan Zee. That victory hinted at his rising dominance — but his latest triumph in Uzbekistan confirms it. Praggnanandhaa’s consistent performances on the international stage have now placed him among the world’s elite, alongside the likes of Carlsen, Firouzja, and Nepomniachtchi. As India continues to rise as a chess powerhouse, Praggnanandhaa’s crowning as national No. 1 serves as both an inspiration and a signal: the next era of Indian chess has well and truly begun.

भोपाल नगर निगम में ₹20 में बन रहे फर्जी जन्म-मृत्यु प्रमाणपत्र, साइबर धोखाधड़ी का बड़ा खुलासा

भोपाल नगर निगम (BMC) ने एक चौंकाने वाला फर्जीवाड़ा उजागर किया है, जिसमें केवल ₹20 में फर्जी जन्म और मृत्यु प्रमाणपत्र ऑनलाइन जारी किए जा रहे थे। यह मामला तब सामने आया जब कोलार निवासी एक महिला अपने बेटे के जन्म प्रमाणपत्र में उपनाम संशोधन के लिए नगर निगम कार्यालय पहुंची। नगर निगम के जन्म-मृत्यु पंजीयन काउंटर पर कार्यरत विषाल प्रजापति को दस्तावेज़ में कुछ गड़बड़ियां नजर आईं। प्रमाणपत्र देखने में एकदम असली लग रहा था, लेकिन जब उसे सरकारी पोर्टल पर स्कैन किया गया तो उसकी कोई एंट्री नहीं मिली। गहराई से जांच करने पर पता चला कि यह प्रमाणपत्र एक फर्जी वेबसाइट से तैयार किया गया था, जो दिखने में सरकारी पोर्टल जैसी ही थी। नगर निगम ने इस मामले में गोविंदपुरा थाने में FIR दर्ज करवाई है और साथ ही शहर की क्राइम ब्रांच में भी शिकायत दी गई है, क्योंकि आशंका है कि ऐसे कई फर्जी प्रमाणपत्र पहले ही जारी हो चुके हैं। कैसे पहचानें असली और फर्जी वेबसाइट? नगर निगम के अधिकारियों ने नागरिकों को आगाह किया है कि वे बिचौलियों के चक्कर में न पड़ें और केवल सरकारी पोर्टल से ही आवेदन करें। फर्जी वेबसाइट की पहचान करने के लिए ध्यान रखें: BMC के जन्म-मृत्यु प्रमाणपत्र शाखा के रजिस्ट्रार सत्यप्रकाश बड़गैंया ने बताया कि फर्जी प्रमाणपत्र पर डिजिटल सिग्नेचर भी हूबहू असली जैसा बनाया गया था, जिससे साइबर धोखाधड़ी की गंभीरता उजागर होती है। आश्चर्यजनक रूप से, इस फर्जी वेबसाइट पर किसी दस्तावेज़ की सत्यापन प्रक्रिया नहीं थी – लोग सिर्फ ₹20 ऑनलाइन भुगतान कर सीधे फर्जी प्रमाणपत्र डाउनलोड कर सकते थे। अगला कदम पुलिस अब इस पूरे नेटवर्क की जांच में जुटी हुई है, और जल्द ही वेबसाइट बनाने वाले और इस फर्जीवाड़े में शामिल लोगों के खिलाफ कड़ी कार्रवाई की जाएगी। नगर निगम ने नागरिकों से अपील की है कि वे किसी भी संदिग्ध लिंक या वेबसाइट से सावधान रहें और प्रमाणपत्रों से संबंधित सभी कार्य केवल आधिकारिक पोर्टल से ही करें।

नाबालिग से दुर्व्यवहार मामले में रिया यादव और अन्य आरोपियों की जल्द होगी रिमांड, बड़े गिरोह की आशंका

भोपाल में नाबालिग पीड़िता के साथ कथित दुर्व्यवहार के मामले में पुलिस अब मुख्य आरोपी रिया यादव और अन्य गिरफ्तार आरोपियों की न्यायिक रिमांड लेने की तैयारी में है। यह मामला एक पूल पार्टी के दौरान सामने आया था, जहां पीड़िता के साथ घटना हुई। पुलिस को संदेह है कि यह केवल एक isolated मामला नहीं है, बल्कि इसके पीछे एक संगठित गिरोह काम कर रहा हो सकता है, क्योंकि सभी आरोपी आपस में अच्छी तरह से परिचित थे और पार्टियों में लगातार मिलते रहते थे। पुलिस अधिकारियों के मुताबिक, मामले के कई पहलुओं की जांच अभी बाकी है और विस्तृत पूछताछ के लिए कुछ आरोपियों को हिरासत में लेकर रिमांड पर लेना जरूरी है। इस प्रक्रिया के लिए कोर्ट में अर्जी दी जाएगी। वहीं, मामले में एक अहम भूमिका निभाने वाली माही की अब तक गिरफ्तारी नहीं हो पाई है। पुलिस का मानना है कि माही से पूछताछ से न केवल इस मामले की कड़ियाँ जुड़ेंगी, बल्कि पूरे नेटवर्क का खुलासा भी हो सकता है। हालांकि, माही की लोकेशन ट्रेस करने का प्रयास किया जा रहा है, लेकिन उसका स्थायी पता न होने के कारण पुलिस को उसे पकड़ने में मुश्किल हो रही है। अन्य आरोपियों से पूछताछ में सामने आया है कि माही केवल फोन के माध्यम से संपर्क करती थी और उसने कभी भी अपना ठिकाना किसी को नहीं बताया। पुलिस जांच में यह भी पता चला है कि मुख्य आरोपी रिया यादव, जो कि खुद को इवेंट मैनेजर बताती थी, अक्सर अपने सहयोगियों के साथ मिलकर विभिन्न स्थानों पर डांस और पूल पार्टियों का आयोजन करती थी। करोंद क्षेत्र निवासी रिया, अपनी मां और सौतेले पिता के साथ रहती थी। वह ग्यारहवीं कक्षा के बाद स्कूल छोड़ चुकी है। शुरुआत में वह डांस पार्टियों में मेहमान के तौर पर जाती थी, लेकिन बाद में माही की मदद से खुद ही पार्टी आयोजक बन गई। रिया का बॉयफ्रेंड नावेद, जो आठवीं कक्षा तक पढ़ा है, एक गारमेंट शोरूम में काम करता है। यह मामला शुरुआत में टीटी नगर थाने में दर्ज हुआ था, लेकिन बाद में जांच का जिम्मा बजरिया थाने की प्रभारी शिल्पा कौरव को सौंपा गया। पुलिस का मानना है कि आने वाले दिनों में इस मामले में कई चौंकाने वाले खुलासे हो सकते हैं और अन्य लोगों की गिरफ्तारियाँ भी संभव हैं।

कोलकाता लॉ कॉलेज की छात्रा से कथित दुर्व्यवहार के मामले में चौथी गिरफ्तारी, कॉलेज सुरक्षा गार्ड पकड़ा गया

पश्चिम बंगाल पुलिस ने शनिवार को कोलकाता के एक लॉ कॉलेज में पढ़ने वाली छात्रा के साथ कथित दुर्व्यवहार के मामले में चौथे आरोपी के रूप में कॉलेज के सुरक्षा गार्ड को गिरफ्तार किया है। यह मामला बुधवार शाम का है, जब दक्षिण 24 परगना की रहने वाली 24 वर्षीय छात्रा ने आरोप लगाया कि कॉलेज परिसर में सुरक्षा गार्ड्स के कमरे में उसके साथ कई लोगों ने मिलकर दुर्व्यवहार किया। पीड़िता ने बताया कि उसे छात्र संघ में एक प्रमुख पद देने का वादा किया गया था। इस मामले में गुरुवार को तीन लोगों को पहले ही गिरफ्तार किया जा चुका है — मनोजित मिश्रा (पूर्व छात्र और वर्तमान में कॉलेज में अस्थायी कर्मचारी), प्रामित मुखर्जी (प्रथम वर्ष के छात्र), और जैब अहमद (द्वितीय वर्ष के छात्र)। मिश्रा, जिसे 2021 में कॉलेज के छात्र संगठन से निष्कासित कर दिया गया था, ने 2022 में अपनी डिग्री पूरी की थी लेकिन फिर कॉलेज में एक गैर-शैक्षणिक पद पर लौट आया था। छात्रा ने अपनी शिकायत में कहा कि उसे मिश्रा और अन्य लोगों ने छात्र संघ के कमरे में रुकने के लिए कहा था। वहां उसे बिस्कुट खाने के लिए दिए गए और छात्र संघ में पद का प्रस्ताव दिया गया। बाद में मिश्रा ने विवाह का प्रस्ताव रखा, जिसे अस्वीकार करने पर उसे जबरन सुरक्षा गार्ड्स के कमरे में ले जाया गया, जहां कथित घटना हुई। पीड़िता ने आरोप लगाया कि घटना का वीडियो रिकॉर्ड कर उसे धमकाया गया और विरोध करने पर हॉकी स्टिक से मारा गया। उसने बताया कि जब उसने घबराहट की शिकायत की और रोते हुए विनती की, तब जाकर उसे छोड़ा गया। रात में उसके पिता उसे कॉलेज से घर ले गए। अगले दिन उसने पुलिस में शिकायत दर्ज कराई। जांच अधिकारियों के अनुसार, पीड़िता का चिकित्सीय परीक्षण कोलकाता नेशनल मेडिकल कॉलेज एवं अस्पताल में कराया गया है और कुछ प्रत्यक्षदर्शियों के बयान दर्ज किए गए हैं। शुक्रवार को पुलिस उपायुक्त (दक्षिण उपनगरीय डिवीजन) और संयुक्त पुलिस आयुक्त (अपराध एवं ट्रैफिक) समेत कई वरिष्ठ अधिकारी कॉलेज पहुंचे और मामले की जांच की। (पीड़िता की पहचान गोपनीय रखी गई है, जैसा कि यौन अपराध से संबंधित मामलों में सर्वोच्च न्यायालय के निर्देशों के अनुसार अनिवार्य है।)

Wakefit Files DRHP with SEBI for IPO to Raise ₹468.2 Crore via Fresh Issue

Wakefit Innovations Limited, the home and sleep solutions brand, has filed its Draft Red Herring Prospectus (DRHP) with the Securities and Exchange Board of India (SEBI) to launch its much-anticipated Initial Public Offering (IPO). Company Overview Founded in 2016, Wakefit has grown into India’s fastest-growing indigenous brand in the organised home and furnishings sector, clocking a total income of over ₹1,000 crore as of March 31, 2024. The company offers a diverse portfolio, including: Wakefit sells its products through its own website, COCO (Company-Owned, Company-Operated) stores, and external channels such as e-commerce platforms and multi-brand retail stores. Manufacturing Capabilities Wakefit operates five manufacturing facilities: These units are outfitted with advanced automation systems, including robotic arms and roller belt conveyors, which boost operational efficiency and reduce production waste. For FY24, Wakefit reported: IPO Details The IPO consists of: Use of Proceeds According to the DRHP, Wakefit plans to utilize the proceeds from the fresh issue for: IPO Book Running Lead Managers (BRLMs) With this IPO, Wakefit aims to strengthen its offline presence, enhance manufacturing, and bolster its brand positioning in India’s rapidly growing home solutions space. The move also marks a significant step towards capital market debut for one of India’s most recognizable D2C (direct-to-consumer) brands.

Five Tigers Dead in Karnataka Sanctuary, Suspected Poisoning Sparks Outrage and Probe

In a tragic incident that has shaken wildlife conservation circles, a tigress and her four cubs were found dead on Thursday in the Hoogyam forest range of Karnataka’s Male Mahadeshwara (MM) Hills Wildlife Sanctuary. Officials have termed it the state’s worst single-day tiger death toll at a single location, and poisoning is the leading theory behind the deaths. Suspected Retaliatory Poisoning According to forest officials, the tigress had reportedly killed a cow a few days ago, prompting suspicion that the carcass was laced with poison — a retaliatory act that may have fatally affected the tigress and her cubs after they fed on it. An autopsy will be conducted on Friday to confirm the exact cause of death. Probe Ordered; Criminal Action If Negligence Found Karnataka’s Forest Minister Eshwar Khandre has termed the deaths “unnatural” and ordered a high-level inquiry, demanding a detailed report within three days.“If negligence by forest staff is found, or if the cause is confirmed to be electrocution, poisoning, or any other criminal act, FIRs will be filed,” Khandre said. Sources suggest that human-wildlife conflict in and around the sanctuary — particularly due to frequent cattle kills by big cats — has led some villagers to adopt retaliatory tactics, such as poisoning and illegal snares. Conservation Concerns and Tiger Reserve Delay Karnataka is home to 563 tigers, the second-highest in India after Madhya Pradesh. However, conservationists have long warned that tiger habitats, particularly in the MM Hills region, are under significant pressure due to encroachment and inadequate protection measures. The 906 sq km MM Hills Wildlife Sanctuary has been awaiting tiger reserve status for nearly 15 years, a move conservationists argue could bring better protection, funding, and restrictions on commercial activities. “While tiger reserve status doesn’t guarantee absolute protection, it significantly raises the priority of conservation efforts and restricts harmful activities in core habitats,” said a wildlife expert. National and Global Significance This incident has not only triggered statewide concern but also raised alarms in national and international conservation forums. With India’s global reputation for tiger conservation at stake, the deaths of five tigers in one day underscore the urgent need to balance human-animal conflict and implement protective measures more effectively. The final autopsy report and investigation findings are expected to shed more light on whether this was a tragic accident or a preventable crime — one that could have devastating implications for India’s flagship species and its already vulnerable habitats.

Emergency Was Imposed Because One Family Thought It Was Bigger Than the Nation: Jaishankar

External Affairs Minister S. Jaishankar on Friday strongly criticized the Gandhi family over the imposition of the Emergency in 1975 by then Prime Minister Indira Gandhi, calling it an act driven by a sense of entitlement and arrogance. He asserted that the Emergency happened because “a single family considered itself bigger than the nation.” Jaishankar was speaking at the inaugural event of the Mock Parliament organised by the Bharatiya Janata Yuva Morcha (BJYM) to mark 50 years since the Emergency. Referring to the satirical film Kissa Kursi Ka, he said, “The three words in the film’s title sum up the reason behind the Emergency – it was all about clinging to power.” “When a family considers itself above the nation, things like the Emergency take place,” he said.“The one lesson the Emergency taught us is – never take freedom for granted.” Impact on Society and Democracy The minister highlighted the widespread impact of the Emergency beyond politics. “It was not just a political crackdown. The aim was to break the morale of society. People were arrested without trial, not knowing if or when they would be released,” he said. He further pointed out that many who weren’t even politically active were affected. “Those who were politically involved knew arrest was inevitable. Those who weren’t were still not spared.” Backdrop of the Emergency Jaishankar outlined the political background of the time, stating that although Indira Gandhi won the 1971 elections, her government quickly became unpopular due to corruption and inflation. He said, “There were public agitations in Gujarat and Bihar, and serious questions were being raised about the business dealings of the then ‘yuvraj’.” The turning point came when the Allahabad High Court ruled Indira Gandhi guilty of electoral malpractices and misuse of government machinery. Instead of resigning or accepting the verdict, she imposed the Emergency, and the then-President Fakhruddin Ali Ahmed signed the proclamation. Civil liberties were suspended, the press was gagged, and political opponents and activists were thrown into jail, marking what Jaishankar described as the “darkest day of Indian democracy.” Indirect Swipe at Rahul Gandhi In a veiled reference to Congress leader Rahul Gandhi, Jaishankar remarked that some people may be “carrying the Constitution in their hands, but their intentions are different.” He said political parties have their own “DNA”, and that the Congress party has never expressed regret for the Emergency or acknowledged it as a mistake. Samvidhan Hatya Diwas This year marks 50 years of the Emergency, imposed on June 25, 1975. Prime Minister Narendra Modi has reportedly directed that legal records of the Emergency period be preserved for historical purposes. In concluding remarks, Jaishankar stated, “The people of India remember this day as Samvidhan Hatya Diwas. On this day, the Indian Constitution was set aside, press freedom was extinguished, and thousands of political leaders, students, and citizens were jailed.It was as if the government placed democracy itself under arrest.”

Kerala Cancer Survey Reveals High Awareness But Low Screening Rates: AMPOK

A recent statewide survey conducted by the Association of Medical and Pediatric Oncologists of Kerala (AMPOK) has revealed a concerning disconnect between cancer awareness and preventive action among Kerala’s population. While general awareness about risk factors like smoking and alcohol remains high, the actual uptake of preventive screenings is alarmingly low. Key Findings: Dr Aju Mathew, organising chairman of AMPOK, said the survey sheds light on both progress and persistent gaps: “While high general awareness is encouraging, the knowledge deficit in specific preventive tools like vaccination and genetic testing, along with low screening rates, is alarming. The influence of celebrity culture on youth substance abuse also needs urgent public health intervention.” Encouraging Signs, Persistent Myths Despite improvements in societal attitudes toward cancer, misinformation persists: Dr Boban Thomas, organising secretary of AMPOK, emphasized the importance of early detection: “Many cancers today are treatable like chronic illnesses. In some types, early detection offers cure rates up to 99%. We need to shift the public mindset from fear to proactive care.” Survey Methodology and Demographics Call to Action AMPOK stresses that this data must serve as a wake-up call for both health authorities and the public. To combat Kerala’s rising cancer burden, the emphasis must shift from awareness alone to actionable preventive care, including: As Kerala grapples with the dual burden of lifestyle changes and an ageing population, early detection and responsible public messaging will be key pillars in the fight against cancer.

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